Figure 3. Posterior Repression of Hox-C6 mRN Translation in the Mouse Embryo
Translation of Hox-C6 mRNA is seen in eight thoracic segments of the day 13 mouse embryo but blocked in the tail region, probably through the action of microRNAs. The inset shows that Hox-C6 mRNA is expressed all the way to the tip of the tail (using a Hox-C6-lacZ gene fusion). Note that the anterior border of expression of the Hox-C6 protein starts in the posterior half of the T1 segment, indicating that the sclerotome has already resegmented (G. Oliver and E.M.D.R., unpublished data; for methods see Oliver et al., 1988).